Santee Nebraska 68760 Santee is the principal village of the Santee Sioux Reservation in Knox County, Nebraska, United States. The population was 424 at the 2020 census. Historical population Census Pop. Note %± 1980 388 — 1990 365 −5.9% 2000 302 −17.3% 2010 346 14.6% 2020 424 22.5%
